John Wayne Casserole Recipe
There’s something undeniably satisfying about a warm, hearty casserole, especially one as rich and flavorful as the John Wayne Casserole. This dish combines seasoned beef, a creamy topping, melty cheese, and a fluffy biscuit layer in a way that’s simply irresistible. It’s the kind of meal that makes you feel at home, even if you’re miles away. Whether you’re cooking for family, hosting a potluck, or just want a cozy dinner, this recipe is perfect. With just a bit of prep, you get a filling, flavorful casserole that’s sure to be a hit.
I first tried this recipe at a neighborhood potluck, where it quickly stole the show. The combination of taco-seasoned beef, tomatoes, corn, and the creamy chive topping was so unexpected yet absolutely perfect. And that biscuit layer? It soaks up all those delicious flavors, making each bite a little different from the last. Since that day, I’ve made this casserole more times than I can count, tweaking it just a bit each time to make it my own.

The origin story of John Wayne casserole
This recipe has some interesting roots. It’s actually named after the legendary actor John Wayne, who was famous for his cowboy roles in Westerns. The original version of this casserole was created as part of a cookbook collaboration with Wayne back in the 1970s. While there are a few versions of this casserole floating around, they all have a similar essence – a base layer, a hearty filling, and a creamy, cheesy topping. Over the years, it’s evolved to include various flavors and ingredients, making it a popular and adaptable dish for home cooks.
Let’s talk ingredients: the essentials and swaps
Every layer in this casserole brings something special. Here’s a quick breakdown:
- Lean ground beef: This is the main protein in the dish, giving it that savory, satisfying taste. You could swap this out with ground turkey or chicken if you want a leaner option.
- Taco seasoning: Adds a little kick and brings out the Tex-Mex flavors. I sometimes make my own with chili powder, cumin, garlic powder, and paprika, but store-bought works great!
- Rotel diced tomatoes and green chilies: These bring tanginess and a bit of heat to the casserole. If you prefer a milder flavor, go for plain diced tomatoes or fire-roasted ones for extra depth.
- Corn: Sweet and crunchy, corn adds color and a bit of natural sweetness. Frozen corn works well here if you don’t have canned.
- Bisquick mix: This makes up the biscuit base. It’s easy and foolproof, but you could use homemade biscuit dough if you’re feeling adventurous!
- Whipped chive cream cheese: The whipped texture makes it easier to spread, and the chive flavor adds an herby twist. Regular cream cheese with a handful of fresh chives would work just as well.
- Mayo: Adds richness and creaminess to the topping. If you’re not a mayo fan, sour cream is a good substitute.
- Mozzarella and cheddar cheese blend: Melts beautifully and adds a gooey, cheesy finish. Feel free to use any cheese you have on hand that melts well.

Kitchen gear: What you need (and what you can skip)
Here’s the essential kitchen gear for this recipe:
- Large sauté pan: For cooking the ground beef and combining the filling. A non-stick pan will make cleanup easier.
- Mixing bowls: You’ll need one for the biscuit dough and another for the cream cheese topping. If you don’t have multiple mixing bowls, you can rinse and reuse.
- 9 x 13 inch baking dish: This is the perfect size to fit all the layers without spilling over. Glass or ceramic both work well.
- Electric mixer: Helps get the cream cheese mixture nice and smooth. If you don’t have one, a strong arm and a spoon will do the trick – just let the cream cheese soften first.
Step-by-step: Building your John Wayne casserole
Ready to get started? Let’s build this casserole step-by-step!
- Preheat your oven to 325°F. It’s always good to start this first so it’s ready by the time you’re done with the prep.
- Brown the ground beef: In a large sauté pan over medium-high heat, add the ground beef and break it up as it cooks. Stir occasionally until it’s fully browned, then drain off any excess grease. This keeps the casserole from getting too oily.
- Add taco seasoning and simmer: Pour in the water and taco seasoning, stirring well to coat the beef. Let it simmer for about 4 minutes to thicken and allow the flavors to blend.
- Combine the vegetables: Add in the diced onions, Rotel tomatoes, and corn, then reduce the heat to low. Stir everything together and let it sit while you work on the biscuit layer.
- Prepare the biscuit base: In a mixing bowl, combine the Bisquick mix with water, stirring until a sticky dough forms. Spread this dough into the bottom of your greased baking dish. I like to wet my hands a bit to help spread the dough evenly.
- Add the ground beef mixture: Spoon the beef mixture over the biscuit dough and spread it out evenly. This layer gives the casserole a hearty, flavorful base.
- Make the creamy topping: In a separate bowl, combine the whipped chive cream cheese, mayo, garlic powder, and salt. Use an electric mixer (or a wooden spoon) to blend until smooth.
- Top it off with cheese: Spread the cream cheese mixture evenly over the beef layer, then sprinkle the shredded mozzarella and cheddar blend on top. This cheesy layer is what will make your casserole golden and bubbly.
- Bake: Place the dish in the oven and bake for about 40 minutes. The top should be melted and just beginning to brown. Let it rest for a few minutes before serving – this will make it easier to slice.

Make it your own: variations and tweaks
This casserole is incredibly versatile, so don’t be afraid to get creative with it:
- Vegetarian version: Swap the ground beef for a mix of black beans and diced bell peppers. You’ll get the same hearty feel, and it’s a great option for Meatless Monday.
- Spicy twist: Add diced jalapeños to the beef mixture or use spicy taco seasoning if you want to turn up the heat.
- Gluten-free: Use a gluten-free baking mix in place of Bisquick to make this casserole suitable for gluten-sensitive folks.
- Extra veggies: Throw in a handful of spinach or diced bell peppers with the corn for a boost of color and nutrients.
- Low-carb: Skip the biscuit layer entirely, and add an extra layer of cheese to the top. This makes it a little closer to a baked dip but still delicious!
I’ve tried a few of these variations myself, and they all bring something unique to the table. The vegetarian version with black beans is especially good if you’re looking to lighten things up.
Serving suggestions: make it look (and taste) amazing
When serving John Wayne casserole, I like to scoop generous portions onto plates and top with a sprinkle of fresh chopped cilantro or green onions for a pop of color. Serve it with a side of mixed greens or a simple Mexican-style corn salad to balance out the richness. If you’re hosting, place the casserole dish in the center of the table and let everyone help themselves – it’s family-style comfort food at its best.
beverage pairings
This casserole pairs well with a variety of drinks. Here are a few refreshing options:
- Iced tea: A classic! Try it with a hint of lemon or mint to cut through the richness.
- Limeade: The tartness complements the taco seasoning and brings a light, zesty element to the meal.
- Horchata: A creamy, cinnamon-flavored rice milk drink that pairs wonderfully with Tex-Mex flavors.
- Sparkling water with lime: Simple, refreshing, and it helps cleanse the palate between bites.
Storage and reheating tips
Leftovers of this casserole are just as delicious! Store any leftovers in an airtight container in the fridge for up to 3 days. To reheat, pop a slice in the microwave for 1-2 minutes, or warm it in a 325°F oven for about 10 minutes if you want to keep that cheese topping nice and melty.
If you’re planning to freeze it, wrap the whole dish tightly in plastic wrap and foil before baking, then freeze for up to 3 months. When ready to bake, thaw it in the fridge overnight, then bake as directed.
Adjusting for different serving sizes
This recipe serves about 6 people, but if you’re cooking for a crowd, it’s easy to double the ingredients and bake it in two dishes. Just keep an eye on it while baking – the larger quantity might need an extra 5-10 minutes. For a smaller portion, halve the ingredients and use an 8 x 8 inch pan; the cooking time should remain roughly the same.

Frequently asked questions
Q: Can I use a different kind of cheese?
A: Absolutely! Feel free to mix it up with Monterey Jack, Colby, or even pepper jack for a little extra kick.
Q: Can I make this ahead of time?
A: Yes! You can prep it up to the point of baking, then cover and refrigerate. When you’re ready to bake, add 5-10 extra minutes to the cooking time.
Q: Is there a substitute for Rotel tomatoes?
A: Regular diced tomatoes work fine, and you can add a small can of green chilies if you want the mild heat.
Q: Can I skip the mayo in the topping?
A: Sure! Substitute with sour cream or Greek yogurt for a slightly tangier flavor.
Q: How spicy is this casserole?
A: It has a mild kick from the taco seasoning and Rotel, but you can make it spicier by adding extra chilies or using spicy taco seasoning.
Give this John Wayne Casserole a try, and let it warm your kitchen and your heart. Don’t be afraid to add your own twist – cooking is all about making it your own. Enjoy!
Print
John Wayne Casserole Recipe
This easy John Wayne Casserole is a cheesy, beefy, Tex-Mex classic. Perfect for family dinners and potlucks, it’s hearty comfort food everyone will love!
- Total Time: 55 minutes
- Yield: 6 1x
Ingredients
- 1 lb lean ground beef
- 1 cup water
- 1 oz taco seasoning
- 1 cup yellow onion, diced
- 20 oz Rotel diced tomatoes with green chilies, drained
- 12 oz corn, canned and drained
- 3 cups Bisquick mix
- 1 cup water
For the Topping:
- 7.5 oz whipped chive cream cheese (Philadelphia)
- 1/2 cup mayonnaise
- 1 tbsp garlic powder
- 1/2 tsp salt
- 2 cups cheese blend (mozzarella and cheddar), shredded
Instructions
- Preheat your oven to 325°F. It’s always good to start this first so it’s ready by the time you’re done with the prep.
- Brown the ground beef: In a large sauté pan over medium-high heat, add the ground beef and break it up as it cooks. Stir occasionally until it’s fully browned, then drain off any excess grease. This keeps the casserole from getting too oily.
- Add taco seasoning and simmer: Pour in the water and taco seasoning, stirring well to coat the beef. Let it simmer for about 4 minutes to thicken and allow the flavors to blend.
- Combine the vegetables: Add in the diced onions, Rotel tomatoes, and corn, then reduce the heat to low. Stir everything together and let it sit while you work on the biscuit layer.
- Prepare the biscuit base: In a mixing bowl, combine the Bisquick mix with water, stirring until a sticky dough forms. Spread this dough into the bottom of your greased baking dish. I like to wet my hands a bit to help spread the dough evenly.
- Add the ground beef mixture: Spoon the beef mixture over the biscuit dough and spread it out evenly. This layer gives the casserole a hearty, flavorful base.
- Make the creamy topping: In a separate bowl, combine the whipped chive cream cheese, mayo, garlic powder, and salt. Use an electric mixer (or a wooden spoon) to blend until smooth.
- Top it off with cheese: Spread the cream cheese mixture evenly over the beef layer, then sprinkle the shredded mozzarella and cheddar blend on top. This cheesy layer is what will make your casserole golden and bubbly.
- Bake: Place the dish in the oven and bake for about 40 minutes. The top should be melted and just beginning to brown. Let it rest for a few minutes before serving – this will make it easier to slice.
Notes
When serving John Wayne casserole, I like to scoop generous portions onto plates and top with a sprinkle of fresh chopped cilantro or green onions for a pop of color. Serve it with a side of mixed greens or a simple Mexican-style corn salad to balance out the richness. If you’re hosting, place the casserole dish in the center of the table and let everyone help themselves – it’s family-style comfort food at its best.
- Prep Time: 15 minutes
- Cook Time: 40 minutes
- Category: Dinner
